Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1421-1424.doi: 10.3969/j.issn.1673-8225.2012.08.020

Previous Articles     Next Articles

Preparation and properties of chitosan/tricalcium phosphate composite scaffolds 

Yan Xue-ping1, Li Shan1, Su Wen-xin2, Song Jing1, He Jian-min3   

  1. 1Stomatological College of Lanzhou University, Lanzhou  730000, Gansu Province, China; 2Second People’s Hospital of Gansu, Lanzhou  730000, Gansu Province, China; 3Dental Center, Gansu Provincial Hospital, Lanzhou  730000, Gansu Province, China
  • Received:2011-07-01 Revised:2011-09-12 Online:2012-02-19 Published:2012-02-19
  • Contact: He Jian-min, Chief physician, Dental Center, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
  • About author:Yan Xue-ping★, Studying for master’s degree, Stomatological College of Lanzhou University, Lanzhou 730000, Gansu Province, China qichongtian2001@ yahoo.com.cn
  • Supported by:

    Small Exploration Project of the Central Universities, No. 223000-860164*

PDF

534

Abstract:

BACKGROUND: Composite scaffolds prepared with appropriate mixing process can make up the insufficient of single material and satisfy the needs of tissue engineering in maximum.
OBJECTIVE: To prepare the chitosan/tricalcium phosphate composite scaffold and explore its feasibility of serving as scaffold for pulp tissue engineering.
METHODS: Chitosan powder was dissolved in small amount of acetic acid solution. The mixture was stirred to uniform, stilled to deaeration. Then pre-cooling and cross-linking were performed. Sponge-like chitosan/tricalcium phosphate composite scaffold was prepared after anther pre-cooling and cross-linking.
RESULTS AND CONCLUSION: Average porosity of the chitosan/tricalcium phosphate composite scaffold prepared by freeze-drying method was 85.78% and the highest porosity was over 90%. The aperture was 100-300 μm. The composite scaffold had a good toughness, and could not be damaged at over 5 mm of axial compression deformation. The cell toxicity was below grade 0 after cultured in the extracts of the materials. The chitosan/tricalcium phosphate composite scaffold can satisfy the basic needs of biomaterials based on its good biocompatibility, cell affinity, and some mechanical properties.

CLC Number: