Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1401-1406.doi: 10.3969/j.issn.1673-8225.2012.08.016

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Preparation, characterization and biocompatibility of high-conductivity compound scaffolds containing biological activity

Zhou Yan1, Cheng Gang-ge1, Yu Xin-guang2, Zhang Qing-wu3, Huang Yong-an1, Dong Lian-qiang1, Zhang Bao-guo1, Zhang Hui1, Shu Cheng1   

  1. 1Department of Neurosurgery, Air Force General Hospital of Chinese PLA, Beijing  100142, China; 2Department of Neurosurgery, Chinese PLA General Hospital, Beijing  100853, China; 3China University of Mining and Technology (Beijing), Beijing  100083, China
  • Received:2011-08-08 Revised:2011-09-20 Online:2012-02-19 Published:2012-02-19
  • Contact: Yu Xin-guang, Doctor, Chief physician, Professor, Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China xinguang_yu@ 263.net
  • About author:Zhou Yan☆, Doctor, Associate chief physician, Department of Neurosurgery, Air Force General Hospital of Chinese PLA, Beijing 100142, China zhouy1974@ hotmail.com

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Abstract:

BACKGROUND: New materials of tissue engineering can not only support the growth of tissues but also stimulate ideal cell response such as angiogenesis. Its conductivity can promote tissue regeneration included nerve.
OBJECTIVE: To prepare a new type of material that combines conductivity and biological activity as an ideal type of alternative material for tissue engineering.
METHODS: The bioactive polysaccharide hyaluronic acid (HA) was combined with the conductive polymer polypyrrole (PPy) to prepare conductive polymer composites containing biologically activity.
RESULTS AND CONCLUSION: PPy/HA bilayer films had the characters of smooth and conductivity. Cell compatibility experiments in vitro showed that the composites could promote the extension of axons. The composites had verified to have a good inertia and can promote the vascularization in vivo. PPy/HA composite biomaterials are suitable for tissue engineering.

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