Abstract:

BACKGROUND: The core of the artificial bone material activating, biological bonding with autologous bone and completion of autologous bone creeping substitution in vivo is vascularization. The occurrence of vascularization is still unclear.
OBJECTIVE: To observe the vascularization of the large segment of bioactive ceramic scaffold implanted into the skeletal muscle for 3 years.
METHODS: Ten male dogs were selected for implanting porous hydroxyapatite-polylactic acid scaffold (diameter of 1.5 cm, length of 4-4.5 cm) in skeletal muscles. Thirty-six months later, three-dimensional digital subtraction angiography (3D-DSA) was performed.
RESULTS AND CONCLUSION: All the dogs underwent operation and 3D-DSA successful and the results were similar. 3D-DSA showed: nutrient arteries derived from the femoral artery and deep femoral artery and pointed to the hydroxyapatite-polylactic acid scaffold, the branches inserted into the hydroxyapatite-polylactic acid scaffold. 3D-DSA is an effective means of observation of vascularization of artificial bone in vivo. The integral arterial and venous blood circulatory system can be established in hydroxyapatite-polylactic acid scaffold implanted in skeletal muscle for 3 years.