Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1327-1330.doi: 10.3969/j.issn.1673-8225.2012.07.044

Previous Articles    

Gene polymorphism of transforming growth factor-beta 1 T869C in healthy Uygur and Kazakh people of Xinjiang and its correlation with vascular function 

Jia Dong-yu, Xu Xin-juan, Liang Xiao-hui, Zhang Jun-shi, Sun Li-hua   

  1. Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-11-09 Revised:2011-12-09 Online:2012-02-12 Published:2012-02-12
  • Contact: Xu Xin-juan, Doctor, Chief physician, Doctoral supervisor, Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China zcxu2002@medmail.com.cn
  • About author:Jia Dong-yu★, Studying for master’s degree, Attending physician, Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China jdy799_1228@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860296*

PDF

392

Abstract:

BACKGROUND: Gene polymorphism of transforming growth factor β1 (TGF-β1) T869C may be related to the genetic susceptibility of vascular functions; and there is ethnic otherness between nationalities.
OBJECTIVE: To investigate the distribution of TGF-β1 T869C gene polymorphism and the difference between the augmentation indexes of central aortic pressure wave reflections in the Kazakh and Uygur people from Xinjiang.
METHODS: A total of 1 181 healthy people from Xinjiang region were involved, including 589 Uygur people and 592 Kazakh people. TGF-β1 T869C polymorphism distribution of the subjects were detected using PCR-RFLP; meanwhile the augmentation indexes of the corresponding central aortic pressure wave reflections were detected. Multiple-factor non-conditional logistic regression analysis was used to analyze the main risk factors which affect the augmentation indexes of central aortic pressure wave reflections.
RESULTS AND CONCLUSION: PCR-RFLP results showed that the genotype frequencies of TGF-β1 T869C site in Uygur people of Xinjiang were as follows: TT type 22.1%, TC type 49.2% and CC type 28.7%. Allele frequencies were as follows: T allele 46.7%, C allele 53.3%. The genotype frequencies of TGF-β1 T869C site in Kazakh people of Xinjiang were as follows: TT type 11.3%, TC type 47.6% and CC type 41%. Allele frequencies were as follows: T allele 35.1%, C allele 64.9%. There were significant differences between the genotypes of TGF-β1 T869C site and the allele frequencies of the two nationalities (P < 0.01). The augmentation indexes of central aortic pressure wave reflections increased with the growth of age; while the augmentation indexes of central aortic pressure wave reflections in the Kazakhs people were significantly higher than that in the Uygur people of the same age or in the older Uygur group (P < 0.01). Multiple-factor non-conditional logistic regression analysis showed that the risk of increased augmentation indexes of central aortic pressure wave reflections in the Kazakhs individuals who carrying C allele was higher than the other factors. These findings indicate that there is ethnic otherness between the distribution of TGF-β1 T869C gene polymorphism in Xinjiang, which may affect the augmentation indexes of central aortic pressure wave reflections, and is related with the vascular sclerosis and aging in the Kazakh people.
 

CLC Number: