BACKGROUND: Research show that knee joint pain is effectively improved by point pressure of six finger to six point, knee rotation and stretching practices.

OBJECTIVE: To perform a multi-center clinical evaluation of six finger to six point and rotation and stretching manipulation in treating degenerative knee joint disease.

METHODS: A total of 216 cases of gonarthritis patients were assigned into experimental group (n=108) and control group (n=108) using multi-center randomized controlled method. Six finger the to six point and rotation and stretching manipulation was adopted in the experimental group. Du Ning’s manipulation was adopted in the control group. The enrolled patients were treated for        20 minutes a time, once every other day for 30 days, 15 times for a course. All patients were followed up on the 15^th day after treatment.

RESULTS AND CONCLUSION: There were significant differences in the knee functional score, pain score and knee active flexion functional score between experimental group and control group before treatment, after a course of treatment and in the follow-up on 15 day after treatment (P < 0.05). The knee function and pain efficacy rate in the experimental group was 82.4% and 63.0% by follow-up investigation on 15 day after treatment; the rates in the control group were significantly lower; i.e. 68.5% and 38.0% (P < 0.05). These findings indicate that six finger to six point and rotation and stretching manipulation can effectively ameliorate the knee joint pain, significantly improve knee walking ability and knee flexion function; the curative effect is safe and effective.