Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1307-1310.doi: 10.3969/j.issn.1673-8225.2012.07.039

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Research and progress of dental hard tissues with dentinogenesis imperfecta

Zhang Ying1, Zou Jing2, Yang Ran1   

  1. 1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu  610041, Sichuan Province, China; 2Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-09-24 Revised:2011-10-25 Online:2012-02-12 Published:2012-02-12
  • Contact: Zou Jing, Chief physician, Professor, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China zoujing1970@126.com
  • About author:Zhang Ying★, Studying for master’s degree, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, Sichuan Province, China zhang_ying20@sina.com

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Abstract:

BACKGROUND: Dentinogenesis imperfecta is an autosomal dominant genetic disease with dysplastic dentin. Currently, most studies on dentinogenesis imperfecta are focused on phenotype analysis and clinical therapy, while the reports on dental hard tissue of dentinogenesis imperfecta are rare.
OBJECTIVE: To summarize the research progress of dental hard tissue with dentinogenesis imperfecta.
METHODS: A computer-based online search of CNKI, PubMed and OVID databases was performed for related articles published between 1999 and 2011, with the key words of “dentinogenesis imperfecta, surface morphology, animal model, enamel dentinal junction, dentinal tubule” in English and Chinese.
RESULTS AND CONCLUSION: Most researchers recognize that the enamel of dentinogenesis imperfecta has normal structure. The lesions are located in enamel dentinal junction. The enamel dentinal junction represents a linear appearance. The dentin represents a structure disturbance with irregular calcification. The number of dentinal tubules reduces. The shape and arrangement of collagen fibers are abnormal. The reasons for the abnormal structures are not clear and need further research.
 

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