Abstract:

BACKGROUND: Strengthen the research of the osteoporosis (OP) model is necessary for the prevention of osteoporotic fractures. 
OBJECTIVE: To summarize the characteristics of OP goat model and provide help for prevention of OP and osteoporotic fractures.
METHODS: A computer-based search on CNKI database and PubMed database 2005-06/2011-02 was performed for the articles about OP model in ovariectomized goats with the key words of “osteoporosis, animal model, goats, ovariectomy” in English and in Chinese. The articles related with the method to establish the OP model, evaluation criteria, changes in bone, were included. The duplicated research and the articles about the establishment of the male animal models of OP were excluded.
RESULTS AND CONCLUSION: Atotal of 48 articles were obtained, and finally, 21 articles were included to summaize according to the inclusion criteria. Convenient source of goats, easy to disposal, and had the automatic ovulation cycle which were similar to adult women, so it was an ideal experimental animal material. A large amount of blood, urine and bone specimens could be ontained from goats, so the goats were the ideal experimental animal to establish the OP model. Castration method (OVX) is a commonly method to establish OP model, the establishment of goats OP model provided a research basement for the development of prevention drug for OP and osteoporotic fractures and the design of implant.