Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1299-1302.doi: 10.3969/j.issn.1673-8225.2012.07.037

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Mechanism and effect of traditional Chinese medicine on promoting osteoblast proliferation and differentiation   

Chen Shu-xiang, Kang Le   

  1. Department of Orthopedics, Wuyi Traditional Chinese Medicine Hospital, (the Affiliated Jiangmen Traditional Chinese Medicine Hospital of Medicine College of Jinan University), Jiangmen  529031, Guangdong Province, China
  • Received:2011-07-14 Revised:2011-09-12 Online:2012-02-12 Published:2012-02-12
  • About author:Chen Shu-xiang, Chief physician, Department of Orthopedics, Wuyi Traditional Chinese Medicine Hospital, (the Affiliated Jiangmen Traditional Chinese Medicine Hospital of Medicine College of Jinan University), Jiangmen 529031, Guangdong Province, China kangletiger@yahoo.com.cn

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Abstract:

BACKGROUND: It is confirmed that traditional Chinese medicine can improve osteoblast proliferation and differentiation. Cell molecular research on the pharmacological mechanism behind this has made great progress.
OBJECTIVE: To summarize the research progress on the mechanisms of osteoblasts proliferation and differentiation induced by traditional Chinese medicine at home and abroad.
METHODS: An online search of CNKI, PubMed and ScienceDirect databases was performed for articles on the mechanism of osteoblast proliferation and differentiation induced by traditional Chinese medicine, published between January 2000 and December 2010, using keywords of “traditional Chinese herbs, osteoblasts, proliferation, differentiation and mechanism”. A total of 176 articles were collected after initial search, and 30 of them were retained.
RESULTS AND CONCLUSION: Traditional Chinese medicine can improve osteoblast proliferation and differentiation by regulating the genes, signal pathways, cytokines, OPG/RANK/RANKL system of osteoblasts and estrogen-like biological activities. The mechanism is clear. It has a good future prospect for the application of traditional Chinese medicine in bone tissue engineering.

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