Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1295-1298.doi: 10.3969/j.issn.1673-8225.2012.07.036

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Effect of Gu Shi Ning capsule on the hemoglutination mechanism in steroid-induced avascular osteonecrosis of the femoral head

Sun Zhi-tao1, Zhou Zheng-xin2, Niu Wei3, Li Chun-feng4, Ding Hao5   

  1. 1Guangzhou University of Chinese Medicine, Guangzhou  510405, Guangdong Province, China; 2First Affiliated Hospital, University of Anhui Traditional Chinese Medicine, Hefei  230031, Anhui Province, China; 3Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou  510120, Guangdong Province, China; 4Taihe Hospital of Traditional Chinese Medicine, Taihe  236607, Anhui Province, China; 5Wuhu Hospital of Traditional Chinese Medicine, Wuhu  241000, Anhui Province, China
  • Received:2011-07-14 Revised:2011-08-04 Online:2012-02-12 Published:2012-02-12
  • About author:Sun Zhi-tao☆, Studying for doctorate, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China harrison0611@163.com

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Abstract:

BACKGROUND: Gu Shi Ning capsule is summarized as the effective prescriptions by Professor Ding E in long-term treatment in the steroid induced avascular necrosis of the femoral head (SANFH) clinical practice.
OBJECTIVE: To observe the effect of Gu Shi Ning capsule on mechanism of blood coagulation in animal models with SANFH.
METHODS: Rabbit model of femoral head necrosis was constructed with the modified method of the escherichia coli endotoxin plus methylprednisolone. Six white rabbits were randomly selected as the normal control group, while the rest 90 rabbits were randomly divided into: high-dose group of Gu Shi Ning capsule [4.23 g/ (kg•d)], middle-dose group of Gu Shi Ning capsule   [1.41 g/( kg•d)], low-dose group of Gu Shi Ning capsule [0.47 g/( kg•d)], model group and control group. Animals in each of group at 4, 8, 12 weeks after treatment, changes of each indicator was detected.
RESULTS AND CONCLUSION: Compared with the other five groups, thromboxane B2 (TXB2), GMP-140 and thrombomodulin level were higher, but 6-keto-PGF1α was lower at each time in the model group (P < 0.01 or P < 0.05). TXB2, GMP-140 and thrombomodulin were decreased but 6-keto-PGF1α was increased with time of Gu Shi Ning treatment, which in the middle-dose group was better than the high-dose and low-dose groups (P < 0.01 or P < 0.05). It is indicated that Gu Shi Ning capsules can be effectively improve the steroid-induced femoral head necrosis in intravascular coagulation status, so as to achieve prevention and treatment SANFH role.

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