Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1285-1289.doi: 10.3969/j.issn.1673-8225.2012.07.034

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Design and application of a new ventral spinal cord injury impactor

Jiang Shu-dong, Hong Yi, Bai Jin-zhu, Zhang Jun-wei, Zhen Qiao-xia, Li Jian-jun   

  1. Department of Orthopaedic Surgery, China Rehabilitation Research Center for Spinal Surgery, Capital Medical University, Beijing  100068, China
  • Received:2011-11-17 Revised:2011-12-26 Online:2012-02-12 Published:2012-02-12
  • Contact: Li Jian-jun, Master, Professor, Doctoral supervisor, Department of Orthopaedic Surgery, China Rehabilitation Research Center for Spinal Surgery, Capital Medical University, Beijing 100068, China
  • About author:Jiang Shu-dong☆, Doctor, Attending physician, Department of Orthopaedic Surgery, China Rehabilitation Research Center for Spinal Surgery, Capital Medical University, Beijing 100068, China whyjsd@126.com
  • Supported by:

    the National Natural Science Foundation of China,No. 30801222*

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Abstract:

BACKGROUND: At present, the research on the spinal cord injury (SCI) is mainly depend on the animal model, each kind of SCI model has its adapted area and inadequate.
OBJECTIVE: To design and manufacture a ventral SCI impactor model of rats, then evaluate the performance of the device in rat SCI experiment.
METHODS: The chart paper of the ventral SCI impactor was made and then the device was established according to the chart paper. The SD rat ventral SCI model was made by the device. The models were divided into three groups randomly, moderate injury group, severe injury group and control group. Moderate injury group needed a beat of 23 V, severe injury group needed a beat of 25 V, no beat in the control group.
RESULTS AND CONCLUSION: The BBB score in the severe injury group was significantly lower than that in the moderate injury group (P < 0.001), BBB score was linearly related to spinal cord residual tissue (P < 0.001). 23 V voltage power and 30% cord deformation rate results in the moderate injury model, 25 V voltage power and 61% cord deformation rate results in the severe injury model. This ventral spinal cord injury device can reliably produce moderate and severe cord injury models, and it is used easily. The injury force is controllable and the spinal deformation is measurable.

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