Abstract:

BACKGROUND: High-intensity focused ultrasound can induce tissue damages.
OBJECTIVE: To study the damage effect of focused ultrasound on the tissues of sheep liver and spleen.
METHODS: Focused ultrasounds with different intensities and different methods were used to radiate the livers in vivo, livers and spleens in vitro of five sheep. Visual and pathological changes were observed after radiation.
RESULTS AND CONCLUSION: The immediate damage of tissues of livers in vitro with focused ultrasound was more severe than the livers in vivo after 1 week of radiation therapy; in therapies with different intensities, the tissue damage of “#” method was more severe than “=” method in both in vivo and in vitro sheep livers; no significant damage was observed in sheep spleens in vitro with radiation therapies with different intensities and methods; focused ultrasound radiation of III file and “#” method resulted in a great number of hepatic cells with focal degeneration and coagulative necrosis; focused ultrasound radiation of IV file and “#” method on in vivo sheep liver tissues resulted in inflammatory fibrous granulomatous nodules under envelope and coagulative necrosis in large central areas; focused ultrasound radiation of IV file and “#” method on sheep liver tissues in vitro resulted in scattered hepatic lobule structures in most regions under envelope, significantly expanded hepatic sinus and significantly narrower hepatic cords, messy and unclear. Focused ultrasound with III file and “#” methods can damage sheep hepatic cells selectively according to design requirements, and provided experimental basis of treatment of allergic rhinitis.