Abstract:

BACKGROUND: Toll like recptor-4 plays a key role in anti-infection immunity. Recently, Toll like recptor-4 has also been reported as an important moderator in noninfective inflammation reactions, including autoimmune diseases and tissue damage, such as myocardial infarction and cerebral infarction.
OBJECTIVE: To investigate the effect of Vinorelbine on the expression level of Toll like recptor-4 in mouse tail vein endothelial cells.
METHODS: A number of 20 BALB/c mice were randomly divided into to experimental group and control group. Experimental mice were injected with Vinorelbine, while the control mice were injected with saline.
RESULTS AND CONCLUSION: At the 48th hour after Vinorelbine injection, mouse tail vein endothelial cells became disrupted, and the tail vein presented phenomena of thrombosis and inflammatory cell infiltration. Toll like recptor-4 was positive in endothelial cells of damage location. In the control group, the tail vein vessels were intact and Toll like recptor-4 expression in endothelial cells was negative or very low. The results indicate that Toll like recptor-4 expression is up-regulated by Vinorelbine in mouse tail vein endothelial cells. It suggests that Toll like recptor-4 may involve in the development of vein vascular endothelial injury induced by Vinorelbine.