Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1153-1156.doi: 10.3969/j.issn.1673-8225.2012.07.004

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Effect of electrical stimulation combined with exercise on the changes of bone metabolism and serum markers in postmenopausal osteoporosis rats

Qin Rong-zhou, Xie Jiang-tao   

  1. Department of Physical Education, Aba Teachers College, Wenchuan  623002, Sichuan Province, China
  • Received:2011-12-01 Revised:2012-01-06 Online:2012-02-12 Published:2012-02-12
  • About author:Qin Rong-zhou, Lecturer, Department of Physical Education, Aba Teachers College, Wenchuan 623002, Sichuan Province, China qrz100@126.com

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Abstract:

BACKGROUND: Both electrical stimulation and exercise has good effects on the bone metabolism of ovariectomized rats, but research on combined intervention of electrical stimulation and exercise in the ovariectomized rats is rare.
OBJECTIVE: To observe the effect of appropriate exercise prescription combined with electrical stimulation on postmenopausal osteoporosis.
METHODS: The rats were divided into sham, osteoporosis model, exercise, electrical stimulation, and exercise+electrical stimulation groups, and the osteoporosis models of the last four groups were established and corresponding interventions were performed.
RESULTS AND CONCLUSION: Compared with the sham group, osteocalcin concentration in the exercise+electrical stimulation group was increased (P < 0.05), and tartrate-resistant alkaline phosphatase activity was decreased (P < 0.01) but estradiol levels were significantly increased (P < 0.05) in the exercise, electrical stimulation and exercise+electrical stimulation groups at 60 days after intervention. The results confirmed that exercise prescription combined with the low frequency electrical stimulation can promote bone formation, inhibit bone resorption, reduce osteoclasts secrete and prevent bone loss in the rats model of osteoporosis.

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