Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1150-1152.doi: 10.3969/j.issn.1673-8225.2012.07.003

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Influence of Ipriflavone on distraction osteogenesis

Liu Xing-guang1, Zhang Zhi-chun1, 2, Zou Ji-rong2   

  1. 1Liaoning Medical College, Jinzhou  121001, Liaoning Province, China; 2Jinzhou Stomatological Hospital, Jinzhou  121001, Liaoning Province, China
  • Received:2011-12-02 Revised:2011-12-31 Online:2012-02-12 Published:2012-02-12
  • Contact: Zhang Zhi-chun, Professor, Liaoning Medical College, Jinzhou 121001, Liaoning Province, China; Jinzhou Stomatological Hospital, Jinzhou 121001, Liaoning Province, China 1423554636@qq.com
  • About author:Liu Xing-guang★, Studying for master’s degree, Liaoning Medical College, Jinzhou 121001, Liaoning Province China 332770282@qq.com
  • Supported by:

    Liaoning Natural Science Foundation, No.2009A463*

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Abstract:

BACKGROUND: The reports have shown that suitable concentration of Ipriflavone can promote the proliferation and differentiation of frontal osteoblasts of chick embryo, improve the alkaline phosphatase activity, increase the mineralization capacity of osteoblast and promote bone formation. 
OBJECTIVE: To observe the effect of Ipriflavone on distraction osteogenesis of rabbits through implanted-distraction device.  
METHODS: Forty Japanese white rabbits were used to establish the mandibular distraction osteogenesis models, and induced with Ipriflavone. At 1 day, 1, 2 and 3 weeks after distraction, the serological examination was preformed, and the expression of transforming growth factor-β1 at different time points was observed by immunohistochemistry.
RESULTS AND CONCLUSION: At 1 day, 1, 2 and 4 weeks after distraction, there was trabecular bone in the model induced with Ipriflavone, the osteoblasts were increased, and the alkaline phosphatase activity and transforming growth factor-β1 expression was increased (P < 0.05). Ipriflavone can effectively accelerate bone formation in distraction osteogenesis.
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