Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (7): 1141-1144.doi: 10.3969/j.issn.1673-8225.2012.07.001

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Effect of innervation on bone healing after tooth extraction

Lin Hai3, Wang Cheng-yong1, 2, Wang Jin3, Lu Meng1, 2, Chen Wei-hui1, 2, 3   

  1. 1Prevention and Cure Laboratory of Teeth Maxillofacial Deformity, Fujian Medical University, Fuzhou  350001, Fujian Province, China; 2Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou   350001, Fujian Province, China; 3College of Stomatology, Fujian Medical University, Fuzhou  350001, Fujian Province, China
  • Received:2011-10-01 Revised:2011-11-05 Online:2012-02-12 Published:2012-02-12
  • Contact: Chen Wei-hui, Doctor, Master’s supervisor, Associate professor, Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
  • About author:the National Natural Science Foundation of China, No. 31070838*

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Abstract:

BACKGROUND: New bone formation and bone mass maintenance in extraction sockets is regulated by many factors in vivo. Nervous system regulates the bone metabolism by mediating osteoblasts and osteoclasts.
OBJECTIVE: To study the effect of innervation on bone healing and to probe the relationgship between innervation and bone healing in extraction sockets.
METHODS: Dog unilateral inferior nerve was sectioned to establish an animal denervation model.The normal side was used as comparison. After model construction, the premolar of denervated side and normal side were extracted. Imagelogy method was used to test the bone formation and bone mass maintenance in the extraction sockets in the 2nd, 4th, 8th and 12th weeks.
RESULTS AND CONCLUSION: The height, width and CT values in extraction socket bone defect sites of the experiment group was significantly lower than that of the control group (P < 0.01). The height of the buccal alveolar ridge in experiment group was significantly lower than that in the control group (P < 0.05 or P < 0.01). The height of the lingual alveolar ridge of experiment group was significantly higher than that of the control group (P < 0.05 or P < 0.01). These findings indicate that innervations play an important role in the regulation of bone formation and bone mass maintenance in the extraction sockets; there is a close relationship between them.

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