Abstract:

BACKGROUND: Stem cells secrete numerous types of wound healing related factors.
OBJECTIVE: To review the feasibility of stem cell-secreted factors in the treatment of refractory wound, and the possible regulation and repairing mechanism.
METHODS: A computer-based online search of Google, Pubmed Database and Wanfang Database were performed for articles and reviews. The key words were “chronic wound, refractory wound, cutaneous, wound healing, wound repair, diabetic wound, stem cell-derived conditioned medium, cellular cytokine solution” in English, and “would repair, injury repair” in Chinese. A total of 57 articles were retrieved, and screened following reading titles and abstracts. Literatures about stem cell-secreted wound healing related factors were included. Repetitive and poor quality articles were excluded. Finally, 34 literatures were included.
RESULTS AND CONCLUSION: Stem cell-derived conditioned medium contains numerous wound healing related factors, which can be used as an alternative in treating refractory wound. However, stem cells from different sources or in different cultivation conditions will produce different secretions, thus further exploration is needed to resolve issues such as which kind of stem cells should be used to generate conditioned medium, how to stimulate stem cells to largely produce wound healing related factors, how frequent and at what dosage and timing should stem cell-derived conditioned medium be optimally applied.