Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1115-1118.doi: 10.3969/j.issn.1673-8225.2012.06.036

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Advances of stem cells transplantation for hepatic disease

Xing Xiu-wei1, 2, Li Jian-sheng1   

  1. 1Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China; 2Shangqiu Medical College, Shangqiu  476100, Henan Province, China
  • Received:2011-11-17 Revised:2011-12-19 Online:2012-02-05 Published:2012-02-05
  • Contact: Li Jian-sheng, Doctor, Professor, Chief physician, Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China lijiansheng@medmail.com.cn
  • About author:Xing Xiu-wei★, Studying for master’s degree, Resident physician, Associate lecturer, Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; Shangqiu Medical College, Shangqiu 476100, Henan Province, China sqyzxxw1983@163.com

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Abstract:

BACKGROUND: In the recent years, stem cells transplantation in the treatment of hepatic disease is a hot research spot for many scholars. The research of the basic theory and clinical application about stem cells transplantation has greatly developed. 
OBJECTIVE: To briefly review several aspects of stem cells transplantation, such as the theoretical basis of stem cells transplantation, stem cell sources, ways of transplantation, the experimental and clinical research, the existing problems and prospects.
METHODS: The CNKI database and Pubmed database (during 2001-01/2011-11) were used to search the related articles about stem cells transplantation in the treatment of hepatic disease. The retrieval keywords were “stem cell, transplantation and hepatic disease, hepatic injury” in English and Chinese. There were 192 articles by the initial retrieval. Then 31 articles were remained according to the inclusion criteria. 
RESULTS AND CONCLUSION: Stem cells had adequate sources, and it was easy to obtain. Stem cells could be cultivated and proliferate in vitro. The technology of stem cells transplantation had many advantages, such as the simple operation and high safety. Especially autologous stem cells transplantation could completely avoid transplant rejection. However, the effectiveness and safety of autologous stem cells transplantation for the treatment of hepatic disease was still unclear, a long-term observation was needed to be done.

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