Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1111-1114.doi: 10.3969/j.issn.1673-8225.2012.06.035

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Current researches of signal pathways involved in bone marrow mesenchymal stem cells differentiation into nerve cells  

Liu Zhen-dong, Wang Jing-cheng, Yang Jian-dong   

  1. Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou  225001, Jiangsu Province, China
  • Received:2011-06-03 Revised:2011-08-04 Online:2012-02-05 Published:2012-02-05
  • Contact: Wang Jing-cheng, Professor, Master’s supervisor, Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou 225001, Jiangsu Province, China 001wjc@sina.com
  • About author:Liu Zhen-dong★, Studying for master's degree, Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou 225001, Jiangsu Province, China liu-zhd@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81071466*

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) can be induced to differentiate into nerve cells in appropriate culture conditions.
OBJECTIVE: To review various signal pathways referred to the process of BMSCs differentiation into nerve cells.
METHODS: The databases of CNKI and Web of Science were searched for the articles about BMSCs differentiation into nerve cells published from January 2001 to December 2010. The key words were “bone marrow mesenchymal stem cells, neural cells, signal” in Chinese and English. Finally, 19 articles were included in result analysis.
RESULTS AND CONCLUSION: The relationship between cell signaling pathways is complex, and thus it is more accurate for the regulation of cell-specific responses. A series of signal transduction pathways involved in the regulation of bone marrow mesenchymal stem cells differentiate into nerve cells, including Ca2+ signaling pathway, protein kinase A signaling pathway, MEK-ERK pathway, PI3K/AKt signaling pathway, MAPK signaling pathway, which are interrelated with each other.

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