Abstract:

BACKGROUND: Studies have shown that the serum human chorionic gonadotropin β-subunit levels in pregnant women after in vitro fertilization and embryo transfer can predict the pregnancy outcomes. It is unknown whether in the in vitro maturation, it can be a predictive index for the pregnancy outcomes.
OBJECTIVE: To evaluate the value of serum human chorionic gonadotropin β-subunit levels in the prediction of pregnancy outcome in women undergoing in vitro maturation, and to compare serum human chorionic gonadotropin β-subunit levels in infertility patients after in vitro maturation and in vitro fertilization and embryo transfer.
METHODS: A total of 42 successfully treated pregnant women who received in vitro maturation were enrolled as experiment group; and 66 women who received in vitro fertilization treatment at the same time were enrolled as control group. Retrospective analysis was used to compare the serum human chorionic gonadotropin β-subunit levels in both groups on day 14 after embryo transfer.
RESULTS AND CONCLUSION: There was a significant difference in the serum human chorionic gonadotropin β-subunit levels between single pregnancy and gemellary pregnancy in both model group and control group on day 14 after embryo transfer. The incidence of gemellary pregnancy increased significantly in both groups when the serum human chorionic gonadotropin β-subunit level≥ 800 U/L. These findings indicate that human chorionic gonadotropin β-subunit level is a valuable index for the prediction of pregnancy outcome in women received in vitro maturation. The prediction of pregnancy outcomes in women who received in vitro maturation was similar to that in women who received in vitro fertilization and embryo transfer.