Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 766-770.doi: 10.3969/j.issn.1673-8225.2012.05.002

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Low-intensity pulsed ultrasound combined with periodontal flap surgery for the repair of bone-defect periodontitis in Beagle dogs

Li Na1, Lu Li2, Song Jin-lin1, Deng Feng1, Zhao Chun-liang3, Wang Zhi-biao3   

  1. 1Department of Orthodontics, Brach of Ran Jia Ba, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing  401147, China; 2Department of Stomatology, the Second Affiliated Hospital, Third Military Medical University, Chongqing  400037, China; 3Chongqing Key Laboratory of Ultrasound Medical Engineering, Chongqing  400016, China
  • Received:2011-09-20 Revised:2011-11-15 Online:2012-01-29 Published:2012-01-29
  • Contact: Song Jin-lin, Doctor, Chief physician, Professor, Master’s supervisor, Department of Orthodontics, Brach of Ran Jia Ba, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China soongjl@163.com
  • About author:Li Na★, Studying for master’s degree, Attending physician, Department of Orthodontics, Brach of Ran Jia Ba, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China
  • Supported by:

    the National Natural Science Foundation of China, No. 30870754*; the Major High-Tech Industrial Technology Development Project of Chongqing Municipal Development and Reform Commission, No. 20071110*; Chongqing Health Bureau Research Project, No. 2008-2-254*

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Abstract:

BACKGROUND: In recent years, there are no reports regarding tissue repair effects of low-intensity pulsed ultrasound (LIPUS) combined with periodontal flap surgery treatment on bone-defect periodontitis.
OBJECTIVE: To observe the effects of LIPUS combined with periodontal flap surgery on the repair of bone-defect periodontitis in Beagle dogs.
METHODS: Bone-defect periodontitis models were established in the left mandibular second, third and fourth premolars of four Beagle dogs. The models were randomly divided into a control group (0 mW/cm2) and two LIPUS treatment groups (ISATA
30 mW/cm2×20 min/d, ISATA 60 mW/cm2×20 min/d) after modified Widman flap surgery and root treatment.
RESULTS AND CONCLUSION: There was no significant difference in the change of gingival tissue’s surface temperature before and after LIPUS irradiation (P > 0.05). There was no significant difference of periodontal clinical parameters in the LIPUS and control groups, as well as between the two LIPUS groups after 6 weeks treatment (P > 0.05). Histological analysis (hematoxylin- eosin staining) indicated that osteoblast proliferation and bone lacunae in the LIPUS groups, especially in ISATA 30 mW/cm2×    20 min/d group, were more mature than those in the control group. Masson staining showed red staining was more obvious in the LIPUS groups than in the control group. Long-junction epithelium was found in all the three groups. LIPUS may have some potential reparative effects on the promotion of alveolar bone maturation.

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