Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (3): 495-498.doi: 10.3969/j.issn.1673-8225.2012.03.025

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Synthesis and in vitro bioactivity of mesoporous-macroporous bioactive glass  

Li Yang1, Yan Peng-hua2, Liu Bin1, Wang Jin-qing2   

  1. 1School of Stomatology, Lanzhou University, Lanzhou  730000, Gansu Province, China; 2State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou  730000, Gansu Province, China
  • Received:2011-06-17 Revised:2011-09-24 Online:2012-01-15 Published:2012-01-15
  • Contact: Liu Bin, Doctor, Professor, School of Stomatology, Lanzhou 730000, Gansu Province, China Liubkq@lzu.edu.cn
  • About author:Li Yang★, Studying for master’s degree, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China yangli_1211@ 126.com
  • Supported by:

     the National Natural Science Foundation of China, No. 50801065*; the “Top Hundred Talents Program” of Chinese Academy of Sciences*

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Abstract:

BACKGROUND: As the bone substitute materials, the bioactive glasses with excellent bioactivity and biocompatibility are used to repair the bone defects. Especially, porous bioactive glasses are benefiicial to form bone in virtue of its high specific surface area and pore volume.
OBJECTIVE: To utilize citric acid as a substitution of inorganic acid so as to synthesize self-assembled mesoporous- macroporous bioactive glass (MMBG).
METHODS: Citric acid and P123 were dissolved in ethanol, and the mixture was continuously stirred for 2 hours. Tetraethyl orthosilicate, Ca(NO3)2•4H2O, and triethyl phosphate were then added to the solution and stirred for 24 hours, followed by putting the solution in a beaker for 7 days under static conditions. Finally, calcination was performed for removing the organic composition. Samples were evaluated by immersion studies in simulated body fluid.
RESULTS AND CONCLUSION: The synthesized material had mesoporous-macroporous structure with high porosity and BET surface. The samples also showed good bone-forming activity. It is anticipated that the synthesized MMBG can be used in bone defect repairing and bone tissue engineering.

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