Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 179-182.doi: 10.3969/j.issn.1673-8225.2012.01.039

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Levels of peripheral blood stem cell factors in patients with chronic kidney diseases

Qiu Fang-xin, Zhang Wei, Liang Yao-xian, Liu Xue-mei   

  1. 青岛大学医学院附属医院肾内科，山东省青岛市 266003
  • Received:2011-06-21 Revised:2011-09-07 Online:2012-01-01 Published:2012-01-01
  • Contact: Liu Xue-mei, Doctor, Associate chief physician, Department of Nephrology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China liuxm2004@sina.com
  • About author:Qiu Fang-xin★, Studying for master’s degree, Department of Nephrology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
  • Supported by:

     the Medical and Health Development Project of Shandong Province, No. 2009HW031*; Shandong Province Scientific and Technological Projects 2010, No. 2010G0020222*

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Abstract:

BACKGROUND: Stem cell factor (SCF) is a multifunctional cytokine, which plays a crucial role in the process of renal interstitial fibrosis.
OBJECTIVE: To investigate the changes and clinical significance of serum SCF in patients with chronic kidney disease (CKD).
METHODS: Serum levels of SCF in 22 healthy controls and 116 patients with CKD were detected by enzyme-linked immunosorbent assay. The correlation between serum levels of SCF and renal damage degree, anemia, lipid metabolism disorders, cardiovascular disease, uremic pruritusda was analyzed.
RESULTS AND CONCLUSION: Serum levels of SCF in different CKD groups were significantly higher than that in control group (P < 0.01). Serum SCFs increased with the progression of renal dysfunction (P < 0.05), which were positively related to staging of CKD, serum creatinine, blood urea nitrogen, blood high C-reactive protein, lipids and parathormone, while negatively related to hemoglobin. The results suggested that serum SCF may play an importaut role in progression and medical camplications of CKD.

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