Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (53): 10031-10034.doi: 10.3969/j.issn.1673-8225.2011.53.037

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Clinical application of human hepatocyte transplantation

Ran Jiang-hua1, Liu Jing1, Li Li1, Li Shi-feng2   

  1. 1Liver Transplant Center, First People’s Hospital in Kunming, Kunming  650011, Yunnan Province, China
    2Oklahoma Transplant Center, Oklahoma University Medical Center, Oklahoma City, OK  73104, USA
  • Received:2011-07-12 Revised:2011-10-10 Online:2011-12-31 Published:2011-12-31
  • About author:Ran Jiang-hua☆, Doctor, Chief physician, Professor, Master’s supervisor, Liver Transplant Center, First People’s Hospital in Kunming, Kunming 650011, Yunnan Province, China lqzkm@163.com

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Abstract:

BACKGROUND: Now, source of human hepatocyte is mainly from the marginal donor liver that unused or deemed unsuitable for liver transplantation. Hence the major obstacle for the wide clinic application of human hepatocyte transplantation is the limited supply of donor liver that can provide good quality cells.
OBJECTIVE: To review the clinical actuality and challenge of human hepatocytes transplantation and to summarise the clinical application and difficulty of human hepatocytes transplantation.
METHODS: Wanfang, VIP and PubMed databases were searched from January1990 to September 2010 for literatures concerning human hepatocyte transplantation with the key words of “hepatocyte, transplant, liver failure, hepatocyte source” or “hepatocyte transplantation; liver failure; liver-based metabolic disorders” in Chinese and in English. The articles related to the research on the human hepatocyte transplantation were selected; articles in the same circle published in recent years or in authorized journals. Older articles and repetitive studies were excluded.
RESULTS AND CONCLUSION: Among 213 articles, only 30 met the requirement. Over 80 patients have received human hepatocyte transplantation to treat liver-based metabolic disorders and liver failure around the world. After transplantation, it has shown some early improvement in liver function which showed that hepatocyte transplantation has a wide clinical application. The major challenge is to develop an alternative source of hepatocytes and the survival course of human hepatocytes transplanted into donor liver also need to further improve.

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