Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (49): 9249-9253.doi: 10.3969/j.issn.1673-8225.2011.49.030

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Effect of bone marrow mesenchymal stem cells combined with various scaffold materials:A systematic review

Fang Zhi-hui1, Tan Jin-hai1, Zeng Xian-tao2,Yang Yong-bo1, Li Sheng3   

  1. 1Department of Orthopedics Surgery, Zhongnan Hospital of Wuhan University, Wuhan   430071, Hubei Province, China; 2Department of Stomatology, Affiliated Taihe Hospital, Hubei Medical University, Shiyan  442000, Hubei Province, China; 3Department of Urology Surgery, Zhongnan Hospital of Wuhan University, Wuhan  430071, Hubei Province, China
  • Received:2011-05-16 Revised:2011-06-28 Online:2011-12-03 Published:2011-12-03
  • Contact: Tan Jin-hai, Chief physician, Professor, Department of Orthopedics Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China tanjh@public.wh.hb.cn
  • About author:Fang Zhi-hui★, Studying for master’s degree, Attending physician, Department of Orthopedics Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China 25910033@qq.com

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Abstract:

BACKGROUND: Now, bone marrow mesenchymal stem cells (BMSCs) combined with different biological scaffold materials to composite repair bone defect, but the effectiveness is lack of a systematic review.
OBJECTIVE: To explore the effect of BMSCs combined with different biological bone scaffold materials on repairing bone defect.
METHODS: A computer based online search in CNKI, CBM, VIP and Wanfang to collect the published articles for the randomized controlled trails which using BMSCs as a seed stem cells composite with various scaffold materials from January 1990 to April 2011. Hand searching was also done to obtain any further information about the studies. The quality of the included studies was critically evaluated and data were analyzed.
RESULTS AND CONCLUSION: The results showed that the BMSCs could effective compound with various biological materials, including gelatin sponge, poly lactic acid-glycolic acid copolymer porous materials, hydroxyapatite, calcium phosphate, coral, alginate and chitosan poly lactic acid, calcium sulfate, algal acid calcium, L-polylactide and platelet-rich plasma, and could differentiate to osteoblast. It is indicated that BMSCs can promote the ability of various support materials to repair new bone osteogenesis of bone defect.

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