Abstract:

BACKGROUND: There are few studies about granulocyte-colony stimulating factor related lung injury during mobilization of peripheral blood stem cells, but the mechanism is unclear.
OBJECTIVE: To explore the clinical manifestation and possible pathogenic mechanism of acute lung injury related to recombinant human granulocyte-colony stimulating factor.
METHODS: We reported a case of sudden hemoptysis, scattered lung nodular shadows and patchy shadows in a leukemia patient following the administration of granulocyte-colony stimulating factor to mobilize peripheral blood stem cells, and related literatures were also reviewed.
RESULTS AND CONCLUSION: Granulocyte-colony stimulating factor while mobilizing peripheral blood stem cells could induce acute lung injury, which may involve migration of neutrophils to vascular spaces, adhesion of neutrophils to endothelial cells, and potentiation of proinflammatory cytokine expression.