Abstract:

BACKGROUND: Bone marrow stromal cells (BMSCs) can differentiate into neurons and astrocytes under the appropriate conditions, and secrete soluble molecules to promote neuronal survival.
OBJECTIVE: To observe the effect of test the effect of BMSCs on neurotrophic factors and neurologic function of rats with ischemic cerebral infarction.
METHODS: Rats were subjected to transient middle cerebral artery occlusion and intravenously injected with 3×106 BMSCs (treatment group) and 1 mL normal saline (saline group) at 24 hours after stroke. No administration was done in blank control group.
RESULTS AND CONCLUSION: Significant recovery of neurological function was found in the treatment group at 7 and 14 days after stroke in comparison with the other two groups (P < 0.05). Nerve growth factor and brain derived neurotrophic factor had a higher expression in the treatment group than the other two groups at different time points (P < 0.05). Intravenous injection of BMSCs can improve the neurologic function of rats with ischemic cerebral infarction and the increase in the expression of nerve growth factor and brain derived neurotrophic factor in the ischemic tissue plays an important role in neurological recovery.