Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (45): 8451-8454.doi: 10.3969/j.issn.1673-8225.2011.45.020

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Expression of Mash-1 in hippocampal neural stem cells after cerebral ischemia/reperfusion injury in rats

Lü Wei-li1, Xing Xue-song2, Zhang Ling1, Zhang Min1   

  1. 1Department of Pathology, 2Department of Anatomy, Shenyang Medical College, Shenyang  110034, Liaoning Province, China
  • Received:2011-04-15 Revised:2011-06-13 Online:2011-11-05 Published:2011-11-05
  • Contact: Xing Xue-song, Doctor, Associate professor, Department of Anatomy, Shenyang Medical College, Shenyang 110034, Liaoning Province, China syyxyx@sina.com
  • About author:Lü Wei-li☆, Doctor, Associate professor, Department of Pathology, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
  • Supported by:

    the Scientific Research Program of Liaoning Education Bureau, No. L2010546*

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Abstract:

BACKGROUND: Mash-1 is expressed during the development of the central nervous system and peripheral nervous system, and plays an important role in neurons and glial cell differentiation.
OBJECTIVE: To investigate the expression of Mash-1 in the hippocampus after cerebral ischemia/reperfusion in rats.
METHODS: A novel model of cerebral ischemia/reperfusion was established with the method of middle cerebral artery occlusionin rats. The rats were divided into sham-operation group, and ischemia/reperfusion groups of 3, 7, 14, 21 and 28 days.
RESULTS AND CONCLUSION: After 3 days, BrdU positive cells in the hippocampus were obviously increased. To the 7th day, BrdU positive cells were more than those at any time. Mash-1 reaction products were increased gradually with the time of cerebral ischemia/reperfusion, reached the peak on day 21, and then gradually decreased. The expression of Mash-1 is in a time-depended manner and corresponds to the proliferation and differentiation of neural stem cells, suggesting that Mash-1 can play the important effect in regulating the neural stem cell differentiation in the late stage.

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