Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (45): 8386-8390.doi: 10.3969/j.issn.1673-8225.2011.45.006

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Bone morphogenetic protein-2 combined with adipose derived stem cells for treatment of avascular necrosis of the femoral head in rabbits

Qi Xin-wen, Wang Zhao-jie, Chen Jun-ping, Zhao Jun-yan, An Rong-ze   

  1. Department of Orthopedics, the Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai  51900, Guangdong Province, China
  • Received:2011-07-27 Revised:2011-09-13 Online:2011-11-05 Published:2011-11-05
  • Contact: Wang Zhao-jie , Doctor, Chief physician, Department of Orthopedics, the Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 51900, Guangdong Province, China c3h3qxw@163.com.cn
  • About author:Qi Xin-wen★, Master, Associate chief physician, Department of Orthopedics, the Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 51900, Guangdong Province, China
  • Supported by:

    Zhuhai Municipal Health Bureau of Scientific Research Project, No. 2009069*; 2009 Annual Youth Scientific Research Fund Project of Zunyi Medical College, No. 2009(05) *; Medical Development Project of Zhuhai City, No. 2008[80]*

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Abstract:

BACKGROUND: Adipose derived stem cells (ADSCs) and bone morphogenetic protein-2 (BMP-2) have a strong osteogenic capability that is important for the repair of avascular necrosis of the femoral head.
OBJECTIVE: To observe the combined effects of ADSCs and BMP-2 on avascular necrosis of the femoral head.
METHODS: The avascular femoral head necrosis models were established in 48 rabbits using liquid nitrogen. The rabbits were divided into control group, core decompression group, ADSCs group and BMP-2+ADSCs group randomly. 
RESULTS AND CONCLUSION: Tissue repair of femoral head necrosis in ADSCs group and BMP-2+ADSCs group was vigorous. There were more newly formed trabeculae, which were strengthened. X-ray showed no obvious cystic degeneration and collapse of the femoral head. The growth of trabeculae and bone marrow in BMP-2+ADSCs group was more vigorous than that in ADSCs group at 8 weeks. It is indicated that BMP-2 combined with ADSCs have a stronger repairable ability in necrosis of the femoral head necrosisl.

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