Abstract:

BACKGROUND: Restenosis and other complications after coronary stent implantation have attracted more and more attention.
OBJECTIVE: To systematically evaluate the biocompatibility of biodegradable cardiovascular stent materials.
METHODS: A Computer-based online search of EMbase (1980/2011-08), MEDLINE (1966/2011-12), CBM (1978/2011-08) and CNKI for articles about animal experiments and clinical applications focusing on the biocompatibility of biodegradable cardiovascular stent materials. The included articles were generally analyzed to overall summarize the biocompatibility of biodegradable cardiovascular stent materials.
RESULTS AND CONCLUSION: When the vascular endothelialization is complete, timely degradation of biodegradable stents overcomes thrombosis induced by the stent itself as a foreign body and inhibits early thrombosis and late neointimal hyperplasia, indicating that the stents have good biocompatibility and effectively reduce the restenosis incidence. Biodegradable stents can also be localized as a drug delivery carrier, to effectively prevent acute vascular occlusion and reduce the incidence of restenosis after stent implantation.