Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7897-7901.doi: 10.3969/j.issn.1673-8225.2011.42.026

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Application of collagen/chitosan compound nanofiber membrane in biomedical engineering

Yu Pei-jun, Chen Wei   

  1. Department of Orthopaedics, Shanghai Eighth People’s Hospital of Jiangsu University, Shanghai  200235, China
  • Received:2011-01-05 Revised:2011-03-11 Online:2011-10-15 Published:2011-10-15
  • Contact: Chen Wei, Doctor, Professor, Chief Phycician, Department of Orthopaedics, Shanghai Eighth People’s Hospital of Jiangsu University, Shanghai 200235, China drchenwei@163.com
  • About author:Yu Pei-jun★, Master, Physician, Department of Orthopaedics, Shanghai Eighth People’s Hospital of Jiangsu University, Shanghai 200235, China yupeijun82@163.com
  • Supported by:

    National High Technology Research and Development Program (the 863 Program) of China, No.2008AA03Z305*

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Abstract:

BACKGROUND: Collagen/chitosan compound nanofiber membrane has become a research hotspot in recent years in respects of excellent mechanical properties and good biocompatibility.
OBJECTIVE: To review the research progress of collagen/chitosan compound nanofiber membrane in biomedical engineering.
METHODS: Literatures related to collogen/chitosan compound nanofiber membrane from PubMed database, Elsevier database and Wanfang database (1993-01/2010-05) were retrieved by computer with the key words of “collagen, chitosan, compound nanofiber membrane, collagen/chitosan compound nanofiber membrane” in Chinese and English According to inclusion criteria, 53 literatures were selected in this study．
RESULTS AND CONCLUSION: The studies have demonstrated that collagen combined with chitosan crosslinked under different conditions, its compound had some improvement in mechanical properties of single collagen, and collagen/chitosan compound nanofiber membrane could be served as a small cartilage defect repair scaffold. It has been confirmed that collagen/chitosan compound nanofiber membrane has better mechanical properties, tissue cell compatibility and biodegradability. Collagen and defect of chitosan single material, advantages of compound nanofiber membrane and its application on biomedical engineering have been also discussed.

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