Abstract:

BACKGROUND: Orange daylily active component flavone glycosides has been considered to be able to regulate organism metabolism, get rid of superoxide anion radicals and metabolic waste in vivo, improve liver function and delay the progress of hepatic fibrosis.
OBJECTIVE: To observe the effects of flavone glycosides on liver function in a rat model of hepatic fibrosis.
METHODS: Hepatic fibrosis models were developed by carbon tetrachloride (CCl4) induction, and flavone glycosides was given orally to rats. After 4-week experimentation, blood was selected and alanine aminotransferase (ALT), albumin (ALB), albumin/globulin ratio (A/G), high density lipoprotein (HDL) in serum were detected. Rat food intake, actitives and growth were observed. 
RESULTS AND CONCLUSION: After 4 week experimentation, the mortality was 37.5% and 12.5% in the CCl4 model group and flavone glycosides group, respectively. Another 2 weeks later, rat body mass was significantly decreased in the model group   (P < 0.05). Compared with the negative control group, rat body mass in the flavone glycosides group was not significantly decreased (P > 0.05). Compared with CCl4 model group, liver mass/body mass ratio was slighly decreased in the flavone glycosides group. Compared with CCl4 model group, serum level of ALT, ALB, A/G was significantly decreased in the flavone glycosides group. There was no significant difference in these indices between flavone glycosides group and negative control group. These findings suggest that during the pathological process of hepatic fibrosis, intervention with orange daylily active component flavone glycosides can effectively relieve rat liver damage and improve liver function.