Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (40): 7569-7572.doi: 10.3969/j.issn.1673-8225.2011.40.037

Previous Articles     Next Articles

Bone marrow stromal stem cells for bone nonunion

Chen Dong-xu, Bo Zhan-dong   

  1. Department of Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-02-22 Revised:2011-05-10 Online:2011-10-01 Published:2011-10-01
  • Contact: Bo Zhan-dong, Associate professor, Associate chief physician, Department of Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zdb71718@163.com
  • About author:Chen Dong-xu★, Studying for master’s degree, Department of Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China dongxuchenchen@163.com

PDF

510

Abstract:

BACKGROUND: Stem cells are primitive, unspecialized cells with two main characteristics: the ability for self-renewal indefinitely and the ability to differentiate into distinct lineages of mature cells including osteoblasts and chondrocytes. Simultaneously, bone marrow stromal stem cells are suitable seed cells in bone tissue engineering.
OBJECTIVE: To summarize and analyze the advantage of bone marrow stromal stem cells as seed cells via direct transplantation or its complex stent or transgene for repair of nonunion.
METHODS: Biomedical Bibliographic Database in Western Journals and China National Knowledge Infrastructure were searched for articles concerning bone nonunion, culture and application of bone marrow stromal stem cells to bone nonunion as well as bone tissue engineering published from 1998 to 2011. The key words were “bone marrow stromal stem cells, nonunions, repairing, tissue engineering”. Repetitive articles were excluded. Finally, 23 articles were further summarized.
RESULTS AND CONCLUSION: This article summarized the progress in nonunion and the preponderance of bone marrow stromal stem cells as seed cells, isolation and culture of bone marrow stromal stem cells, osteogenic induction of bone marrow stromal stem cells and repair of nonunion using bone marrow stromal stem cells. The methods bring light prospects for the treatment of nonunion, such as percutaneous implantation of autologous bone marrow mesenchymal stem cells or bone marrow stromal stem cells as seed cells combined with suitable stent materials, or bone marrow stromal stem cells as target cells to introduce endogenous target gene to induce osteogenic formation. However, some problems require further investigations, including purification of bone marrow stromal stem cells, proliferation and suitable condition for differentiation of bone marrow stromal stem cells, percutaneous implantation of autologous bone marrow mesenchymal stem cells in the body is easily lost, so perhaps they cannot form an effective cell concentration at the implanting site; Scaffolds do not completely meet the clinical demand, as well as how to combine bone tissue engineering and gene therapy.

CLC Number: