Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (40): 7560-7564.doi: 10.3969/j.issn.1673-8225.2011.40.035

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Pathogenesis of diabetic foot and stem cells transplantation

Yu Jiang-su, Wang Yan-gang   

  1. Department of Endocrinology, Hospital Affiliated to Medical College of Qingdao University, Qingdao  266003, Shandong Province, China
  • Received:2011-02-22 Revised:2011-04-25 Online:2011-10-01 Published:2011-10-01
  • Contact: Wang Yan-gang , Doctor, Chief physician, Department of Endocrinology, Hospital Affiliated to Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
  • About author:Yu Jiang-su, Department of Endocrinology, Hospital Affiliated to Medical College of Qingdao University, Qingdao 266003, Shandong Province, China

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Abstract:

BACKGROUND: Stem cell transplantation for treatment of diabetic foot is mainly based on in vivo differentiation of stem cells to vascular endothelial cells and smooth muscle cells to secrete a large amount of angiogenic factors to form new blood vessels, improves and restores lower limb blood flow to achieve the purpose of treating lower limb ischemia.
OBJECTIVE: To summarize recent research achievements at pathogenesis of diabetic foot and stem cell transplantation and provide direction for further research.
METHODS: We retrieved PubMed and Sciencedirect Databases for relevant articles published from January 1997 to January 2011. The key words were “diabeticfoot, lowerlimbischemia, neuropathy, microangiopathy, macroangiopathy, stem cell therapy” in English. Finally, a total of 32 articles were included.
RESULTS AND CONCLUSION: Mesenchymal stem cells from umbilical cord, fat tissue and amniotic fluid may be optimal choices by comparison of biological characteristics and transplantation effect with different sources of stem cells. The characteristics are easy to be obtained and separated, and possessing strong proliferative capacity. We need a further research with biological characteristics of stem cells, transplantation dose, opportunity, course and tumorigenicity, etc.

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