Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (39): 7255-7258.doi: 10.3969/j.issn.1673-8225.2011.39.009

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Systemic and local cytokines kinetics in early stage after total hip replacement

Xie Qing-yun1, Wei Meng2, Zhang Bo1, Quan Yi1, Pan Xian-ming1, Kang Xia1, Liu Xi-lin1   

  1. 1Department of Orthopedics, 2Department of Rheumatology and Nephrology, General Hospital of Chengdu Military Command, Chengdu  610083, Sichuan Province, China
  • Received:2011-04-19 Revised:2011-06-23 Online:2011-09-24 Published:2011-09-24
  • Contact: Zhang Bo, Master, Associate chief physician, Department of Orthopedics, General Hospital of Chengdu Military Command, Chengdu 610083, Sichuan Province, China
  • About author:Xie Qing-yun★, Master, Attending physician, Department of Orthopedics, General Hospital of Chengdu Military Command, Chengdu 610083, Sichuan Province, China xqingyun@163.com

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Abstract:

BACKGROUND: Studies about local and subsequent systemic inflammtatory reactions in early stage after total hip replacement are rarely reported.
OBJECTIVE: To investigate the local and systemic cytokine kinetics in early stage after total hip replacement.
METHODS: In 9 patients undergoing total hip replacement, drained blood samples and venous blood samples were taken at wound closure, 1, 4 and 24 hours after operation. Interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), IL-1β and IL-17 release was assessed by enzyme-linked immunosorbent assay (ELISA).
RESULTS AND CONCLUSION: The major findings were significant increases in systemic levels of IL-6 and TNF-α and in local levels of IL-6, and the local levels of these cytokines were significantly higher than the systemic ones after operation (P < 0.05). Besides, there were no significant changes in local and systemic levels of IL-1β and IL-17. The acute sterile inflammation after major orthopaedic surgery is principally characterized by significantly increased local and systemic levels of IL-6. Furthermore, the systemic cytokine levels may not reflect local reactions.

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