Abstract:

BACKGROUND: The severity of inflammatory response is obviously correlated with restenosis after coronary stent implantation. Medical workers attempt to find new ideas for the prevention of stent restenosis and improve the quality of treatment.
OBJECTIVE: To evaluate the clinical prospects and value of various interventions and monitoring tools in the treatment of inflammatory response after coronary stent implantation.
METHODS: An electronic search of EMbase (1980-01/2011-05), MEDLINE (1966-01/2011-05), Chinese Biomedical Literature Database (CBM, 1978/2011-05) and CNKI was performed for relevant articles by using the keywords of “Coronary stent, inflammatory cytokines, inflammation, CRP, restenosis” in Chinese and English.
RESULTS AND CONCLUSION: The clinical trials showed that the inflammatory response after stent implantation significantly increased. Inflammatory responses were decreased to a great extent by using sirolimus-eluting stents added with dexamethasone, celecoxib, and rosuvastatin. Animal studies found that the use of sirolimus-eluting stents could reduce neointimal formation of stent segments and inflammatory area. A variety of interventions can reduce the inflammatory response after stent implantation to reduce long-term restenosis; it can be used to further improve the efficacy with clinical observation.