Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 7005-7008.doi: 10.3969/j.issn.1673-8225.2011.37.039

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Multiple treatments for denervated skeletal muscle atrophy

Chen Bo1, Chen Zhen-bing2, Du Yuan-li1   

  1. 1Department of Orthopedics, People’s Hospital of China Three Gorges University, Yichang  443000, Hubei Province, China
    2Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • Received:2011-04-06 Revised:2011-07-09 Online:2011-09-10 Published:2011-09-10
  • About author:Chen Bo★, Master, Associate chief physician, Department of Orthopedics, People’s Hospital of China Three Gorges University, Yichang 443000, Hubei Province, China chenbo71@sina.com

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Abstract:

BACKGROUND: Following denervation, the loss of contractile function and amyotrophy occur in skeletal muscle, and myofibers show a series of histomorphological changes concerning amyotrophy. With progress in technical levels and theory research, considerable improvement in the treatment effects have been achieved, but it is not satisfactory.
OBJECTIVE: To summarize and discuss the recent progress in treatment methods of denervated skeletal muscles atrophy and provide theoretical evidence for recovery of muscle function.
METHODS: A computer-based retrieval was performed by the first author in the CNKI and Medline databases to search papers published between 2000 and 2010 using key words “denervated, skeletal muscles, atrophy, treatment” in Chinese and English languages. A total of 135 papers were retrieved. According to inclusion and exclusion criteria, 30 papers were included in the final analysis. These included papers were summarized and analyzed from the aspects of physiotherapy, nerve repair and implantation, cell transplantation, drug, gene and traditional Chinese medicine treatment.
RESULTS AND CONCLUSION: Great progress has been recently made in treatment of denervated skeletal muscles. However, the methods used can only alleviate skeletal muscle atrophy to an extent and maintain muscular physiological function for a time period. The mechanism underlying denervated skeletal muscle atrophy has been clarified and the corresponding measures would acquire better therapeutic effects.

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