Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 7000-7004.doi: 10.3969/j.issn.1673-8225.2011.37.038

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Multi-functional perlecan: angiogenesis, chondrogenesis and chondrosteosis

Xu Ke1, Chen Ji-hua1, Tang Li-hui2, Wu Dan1   

  1. 1Department of Prosthodontics, 2Department of Dental Materials, Stomatological Hospital, Fourth Military Medical University, Xi’an   710032, Shaanxi Province, China
  • Received:2011-03-01 Revised:2011-04-02 Online:2011-09-10 Published:2011-09-10
  • Contact: Chen Ji-hua, Professor, Chief physician, Doctoral supervisor, Department of Prosthodontics, Stomatological Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China jhchen@fmmu.edu. cn
  • About author:Xu Ke★, Studying for master’s degree, Department of Prosthodontics, Stomatological Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China 670650738@qq.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30770572*

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Abstract:

BACKGROUND: Perlecan functions in a diverse range which ranges from the regulation of cell growth and adhesion to extracellular matrix assembly. We previously identified a central function for perlecan during angiogenic blood vessel development and injury restoration.
OBJECTIVE: To explore the mechanism of perlecan in tissue development and organogenesis.
METHODS: A computer-based retrieval was performed to search manuscripts published between January 2000 and December 2010 in Sciencedirect and CMCC/CMCI with key words of “perlecan, angiogenesis, cartilage, heparan sulfate, vascular endothelial growth factor.” The manuscripts with the contents of perlecan expression and function published recently or in authoritative journals were included. Manuscripts with repetitive contents or Meta analysis were excluded.
RESULTS AND CONCLUSION: A total of 129 manuscripts were included, and according to inclusion and exclusion criteria, 35 manuscripts were included in the final analysis. Perlecan plays a crucial role in tissue development. The underlying mechanism is possibly due to the interactions of the pericellular environment. Perlecan functions in a diverse range. Perlecan employs the same basic mechanism, based on interactions with growth factors, morphogens and matrix proteins.

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