Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 6995-6999.doi: 10.3969/j.issn.1673-8225.2011.37.037

Previous Articles     Next Articles

Osteocyte metabolism during reconstruction of subchondral bone

Du Ming-chang1, Zu Qi-ming2, Liu Xian-min2, Liu Song-bo2, Chen Yu2, Wang Qi2, Xiang Liang-bi2   

  1. 1Postdoctoral Scientific Research Workstation, 2Department of Orthopedics, Shenyang Military Area Command of Chinese PLA, Shenyang  100016, Liaoning Province, China
  • Received:2011-03-05 Revised:2011-04-06 Online:2011-09-10 Published:2011-09-10
  • Contact: Liu Xian-min, Master’s Supervisor, Professor Department of Orthopedics, Shenyang Military Area Command of Chinese PLA, Shenyang 100016, Liaoning Province, China supervisor Professor, Surgeon_du@ 163.com
  • About author:Du Ming-chang☆, Doctor, Postdoctoral Scientific Research Workstation, Shenyang Military Area Command of Chinese PLA, Shenyang 100016, Liaoning Province, China surgeon_du@ yahoo.cn

PDF

446

Abstract:

BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disorder of a high prevalence that remains the leading cause of disability in aged people. Although articular cartilage breakdown is a major characteristic of OA, several tissues of the joint, including the subchondral bone, play significant roles in the development/progression of OA pathology.
OBJECTIVE: To investigate the changes in structure, osteocyte, related factors and signal pathway of subchondral bone during the development/progression of OA pathology, and analyze the effects of pathological changes of subchondral bone on degeneration of articular cartilage.
METHODS: A computer-based retrieval was performed to research papers in CNKI, PubMed, Medline, Embase databases with the key words “osteoarthritis, subchondral bone, cartilage degeneration, bone reconstruction, and bone metabolism.”The pathological changes of subchondral bone structure and molecular signaling mechanism after destructing bone metabolic equilibrium during the development/progression of OA pathology were analyzed.
RESULTS AND CONCLUSION: According to inclusion criteria, 54 papers were included. Subchondral bone reconstruction progresses throughout the entire process of OA. Metabolism of local osteocytes and abnormal differentiation of stem cells influence cartilage degeneration mutually. Further understanding of the mechanism underlying osteocyte metabolism during the process of subchondral bone reconstruction can provide a new therapeutic target for OA.

CLC Number: