Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 6841-6845.doi: 10.3969/j.issn.1673-8225.2011.37.001

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Alendronate sodium inhibits femoral fracture healing in osteoporosis rats

Luo Yang1, Zhang Liu2, Song Ya-qi2, Tian Fa-ming2, Cheng Tan2   

  1. 1Hebei Medical University, Shijiazhuang   050051, Hebei Province, China
    2Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, Tangshan  063000, Hebei Province, China
  • Received:2011-05-05 Revised:2011-07-20 Online:2011-09-10 Published:2011-09-10
  • Contact: Zhang Liu, Doctor, Chief physician, Professor, Doctoral supervisor, Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China zhliu130@sohu.com
  • About author:Luo Yang☆, Studying for doctorate, Physician, Hebei Medical University, Shijiazhuang 050051, Hebei Province, China luoyanghb@hotmail.com

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Abstract:

BACKGROUND: Alendronate sodium has been preferred for clinical treatment of osteoporosis.
OBJECTIVE: To investigate the effects of alendronate sodium on femoral shaft fracture healing in rats with osteoporosis.
METHODS: The rats were randomly divided into three groups: sham surgery, model and alendronate sodium. The right femoral diaphysis of rats in the model and alendronate sodium groups was fractured transversely at the midshaft and fixed with Kirschner wire at 4 weeks after ovariectomy. The alendronate sodium group rats were subcutaneously administered alendronate sodium after fracture establishment.
RESULTS AND CONCLUSION: At 3 and 6 weeks after fracture establishment, the bone mineral density of the whole femur and distal-segment femur was significantly greater in the alendronate sodium group than in the model group (P < 0.01). Compared with model group, the callus volume was greater, the conversion process of cartilaginous callus towards osseous callus was decreased, femoral fracture healing was slowed, and the number of osteoclasts was significantly decreased (P < 0.05) in the alendronate sodium group. The results demonstrated that alendronate sodium inhibited fracture healing in rats with osteoporosis, and the underlying mechanism may be related to a fact that alendronate sodium inhibits the activity osteoclasts, which slows the callus calcification process.

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