Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (36): 6829-6832.doi: 10.3969/j.issn.1673-8225.2011.36.042

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Effects of bone marrow mesenchymal stem cells transplantation on cardiomyocyte apoptosis related gene and protein expression

Jiang Xiao-ming1, Qu Hong-lin2   

  1. 1Physical Culture Department of Qinzhou University, Qinzhou  535000, Guangxi Zhuang Autonomous Region, China
    2School of Physical Education, Yichun University, Yichun  366000, Jiangxi Province, China
  • Received:2011-03-21 Revised:2011-04-25 Online:2011-09-03 Published:2011-09-03
  • Contact: Qu Hong-lin, Lecturer, School of Physical Education, Yichun University, Yichun 366000, Jiangxi Province, China
  • About author:Jiang Xiao-ming★, Studying for master’s degree, Lecturer, Physical Culture Department of Qinzhou University, Qinzhou 535000, Guangxi Zhuang Autonomous Region, China mdchgyffs@126.com
  • Supported by:

    the Science and Technology Support Program of Jiangxi Science and Technology Bureau, No. 2010BSA12200*

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells can act on myocardial cells, and prevent the occurrence of myocardial injury or secondary lesions.
OBJECTIVE: To analyze the effects of bone marrow mesenchymal stem cells on cardiomyocyte apoptosis related gene and protein expression.
METHODS: The first author searched PubMed and CNIKI databases (1997/2010) for articles regarding bone marrow mesenchymal stem cells, cardiomyocyte apoptosis and gene expression.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells become a hotspot because of its characteristics, such as easy to obtain, strong differentiation capacity, low immunogenicity, no rejection. Bone marrow mesenchymal stem cells can function in myocardial cells and prevent the occurrence of myocardial injury or secondary lesions, mainly through regulation of Bcl-2, Bax, Fas, FasL, Caspase gene and protein expression, to realize the inhibition of cardiomyocyte apoptosis. Bone marrow mesenchymal stem cells have a protective effect and applied value in the performance decline induced by cardiomyocyte apoptosis during the movement.

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