Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (36): 6833-6836.doi: 10.3969/j.issn.1673-8225.2011.36.043

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Umbilical cord mesenchymal stem cell transplantation for treatment of Parkinson's disease in 8 cases

Qiu Yun1, Wang Zheng1, Lu Hong-she2   

  1. 1Department of Digestion, Renji Hospital of Shanghai Jiao Tong University Medical School, Institute of Digestive Diseases, Med-X Laboratory of Shanghai Jiao Tong University, Shanghai  200001, China
    2Stem Cell Transplantation Center, the 455 Hospital of Chinese PLA, Shanghai  200052, China
  • Received:2011-03-06 Revised:2011-05-21 Online:2011-09-03 Published:2011-09-03
  • Contact: Wang Zheng, Associate professor, Associate researcher, Department of Digestion, Renji Hospital of Shanghai Jiao Tong University Medical School, Institute of Digestive Diseases, Med-X Laboratory of Shanghai Jiao Tong University, Shanghai 200127, China zheng.w.dr@gmail.com
  • About author:Qiu Yun★, Studying for master’s degree, Department of Digestion, Renji Hospital of Shanghai Jiao Tong University Medical School, Institute of Digestive Diseases, Med-X Laboratory of Shanghai Jiao Tong University, Shanghai 200127, China qyun200911@yahoo.cn
  • Supported by:

    Pujiang Talents Plan of Shanghai Science and Technology Committee, No. 09PJ1407300*; the National Natural Science Foundation of China, No.30971468*

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Abstract:

BACKGROUND: Neurons of the central nervous system neurons are a kind of terminal cells, and neuron loss caused by any pathological process is an irreversible process.
OBJECTIVE: To observe the curative effect of umbilical cord mesenchymal stem cells (UC-MSCs) implantation in treating Parkinson’s disease (PD).
METHODS: A total of 8 PD patients admitted in the Stem Cells Transplantation Center, the 455 Hospital of Chinese PLA, from August to December 2010, were selected, including 4 males and 4 females, aged 50-78 years. From the second week, the patients received UC-MSCs implantation by carotid artery puncturing. Unified Parkinson’s Disease Rating Scale (UPDRS) was used to evaluate those PD patients’ neural function. Higher scores indicate more severe neurological deficit.
RESULTS AND CONCLUSION: All patients were included in the final analysis without loss. Compared to before transplantation, the UPDRS was significant decreased at 1 month after treatment (P < 0.01). The clinical symptoms, such as tremor, rigidity had obvious improvement. There was no significant improvement concerning the symptoms of slow movement and unstable posture. In addition, no graft versus host disease occurred. UC-MSCs implantation can ameliorate clinical symptoms, as well as improve life quality of PD patients to some extent.

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