Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (36): 6772-6775.doi: 10.3969/j.issn.1673-8225.2011.36.028

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Effects of Zhichan Decoction on intracerebral dopamine and metabolites after neural stem cells transplanted in Parkinson disease rats

Shi Hui-fen1, Lu Yu1, Song Jie2, Li Wen-tao1   

  1. 1Department of Neurology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai  200071, China
    2Shanghai University of Traditional Chinese Medicine, Shanghai  201203, China
  • Received:2011-01-04 Revised:2011-05-29 Online:2011-09-03 Published:2011-09-03
  • About author:Shi Hui-fen, Chief physician, Department of Neurology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai 200071, China shf733@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30772870*

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Abstract:

BACKGROUND: How to make the transplanted neural stem cells differentiated into more dopaminergic neurons, so as to accomplish the plerosis of injured dopaminergic neuron. This problem solving will be the breakthrough progress for the treatment of Parkinson disease (PD).
OBJECTIVE: To study the effects of Zhichan Decoction on substantia nigra dopamine (DA) and metabolites, and the survival and directional differentiation after neural stem cells were transplanted from metabolic pathway in PD rats.
METHODS: PD rats models were established by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. The contents of DA, homovanillic acid (HVA) and 3, 4-dihydroxy phenyl acetic acid (DOPAC) were measured with high-performance liquid chromatography (HPLC). 
RESULTS AND CONCLUSION: Zhichan Decoction could increase the content of DA and DOPAC. But there were no effects on HVA. The Zhichan Decoction has the effect to promote the neural stem cells differentiating into dopaminergic neurons in PD rats; At the same time, it could inhibit DA breaks down, so that the therapeutic effect was achieved.

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