Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (35): 6551-6554.doi: 10.3969/j.issn.1673-8225.2011.35.021

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Perfusion function of rat proximal femur bone marrow and its stability determined using dynamic contrast-enhanced MRI

Zhang Ya-feng1, Cheng Qiong2, Zhu Yong1, Liu Fan1   

  1. 1Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong  226001, Jiangsu Province, China
    2Key Laboratory of Neural Regeneration, Nantong University, Nantong  226001, Jiangsu Province, China
  • Received:2011-06-09 Revised:2011-07-27 Online:2011-08-27 Published:2011-08-27
  • About author:Zhang Ya-feng☆, Doctor, Lecturer, Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China zyfcius@163.com
  • Supported by:

    the Natural Science Foundation of Jiangsu Province, No. BK2010285*; the Natural Science Foundation of Jiangsu Universities, No. 10KJB320015*

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Abstract:

BACKGROUND: Due to improvement of MRI surface coil and new-type contrasts, it is possible to use dynamic contrast-enhanced MRI to measure bone marrow blood perfusion function in rats.
OBJECTIVE: To explore the methodology using dynamic contrast-enhanced MRI to measure the perfusion function of rat proximal femur bone marrow and explore its reliability.
METHODS: Contrast agents were injected from tail vein into Wistar rats. Dynamic contrast-enhanced MRI was measured using 1.5T whole body MRI scanner. One week later, the measurement was repeated. Then, time-signal intensity curve was explored. Maximum enhancement (ME) and enhancement slope (ES) were calculated.
RESULTS AND CONCLUSION: ME of test 1 and test 2 were (140.42±17.17)% and (136.57±13.87)%, respectively. ES of test 1 and test 2 were (3.81±0.17)%/s and (3.71±0.20)%/sec, respectively. There was no statistically significant difference in ME and ES between the two tests. The methodology explored in this study which used dynamic contrast enhanced MRI to measure the perfusion function of rat proximal femur bone marrow were reliable and repeatable.

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