Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6385-6387.doi: 10.3969/j.issn.1673-8225.2011.34.028

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Preparation and characterization of Fe3O4 magnetic particles

Li Li1, Ma Li2   

  1. 1Chengdu Vocational College of Agricultural Science and Technology, Chengdu  611130, Sichuan Province, China
    2College of Bioengineering, XiHua University, Chengdu  610039, Sichuan Province, China
  • Received:2011-05-24 Revised:2011-07-08 Online:2011-08-20 Published:2011-08-20
  • About author:Li Li★, Studying for master’s degree, Chengdu Vocational College of Agricultural Science and Technology, Chengdu 611130, Sichuan Province, China lily112400@yahoo.cn

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Abstract:

BACKGROUND: As a kind of magnetic carrier, magnetic nanometer particles have been used in enzyme immobilization, immunoassay, target drug delivery and cell sorting and so on.
OBJECTIVE: To prepare nanometer Fe3O4 crystal particles with good dispersion stability and relatively strong magnetic.
METHODS: Fe3O4 magnetic particles was synthesized by the chemical co-precipitation, using FeCl2, FeCl3 and NaOH.
RESULTS AND CONCLUSION: The synthetic conditions of Fe3O4 magnetic particles were determined through orthogonal design and the optimum experimental conditions as follows: nFe2+/nFe3+ was 2:1, pH was 11, curing temperature was 90 ℃ and the amount of PEG was 40 mL. Under this condition, the average diameter of Fe3O4 particles was 78 nm, the dispersion stability was the best and the relative size of magnetic was the strongest. It could be seen from scanning electron microscope that Fe3O4 crystal particles were nanometer.

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