Abstract:

BACKGROUND: Compared with traditional thermotherapy method, magnetic fluid hyperthermia (MFH) has good magnetic response, and which can achieve automatic temperature control and targeting of tumor thermotherapy in certain high frequency alternating magnetic field.
OBJECTIVE: To prepare Mn-Zn ferrite (MZF) magnetic nanoparticles, and to observe the inhibition effects of MZF magnetic nanoparticles combined with hepatic artery interventional therapy on rabbit VX2 liver tumor.
METHODS: Rabbit VX2 liver tumor models were established by implanting tumor piece and cell suspension via abdominal incision. At 14 days after modeling, a total 24 rabbits were randomly divided into 4 groups as follows: control group (sodium chloride), MZF group, MZF hyperthermia group, adriamycin group, each groups contain 6 VX2 rabbits. The rabbit hepatic proper artery was selectively catheterized by 3F micro-catheters via right femoral artery. The rabbits of MZF hyperthermia group were exposed to alternating magnetic field for three times. At 14 days after interventional operation, the tumor size of liver tissue was detected and harvested for histopathology examination.
RESULTS AND CONCLUSION: MZF nanoparticles were approximately global and their average diameter was 20-30 nm examined by transmission electron microscope (TEM), and they had good magnetic responsiveness under alternating magnetic field. At 14 days after treatment, large areal necrosis arose in tumor in MZF hyperthermia group, the tumor-inhibiting rate was 70.84% higher than the other groups, and the difference was significant (P < 0.05 or P < 0.01). MZF nanoparticles can absorb electromagnetic waves into heat, through interventional therapy which can significantly inhibit the growth of rabbit VX2 liver tumor.