Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6355-6359.doi: 10.3969/j.issn.1673-8225.2011.34.021

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Effects of humnan acellular amniotic membrane on preventing tendon adhesion after repairing digital flexor tendons by derived tendon in chickens

Hao Peng1, Xiang Zhou2, Luo Jing-cong2, Yang Zhi-ming2   

  1. 1Department of Orthopedic Surgery, Sichuan Provincial Hospital, Chengdu  610072, Sichuan Province, China
    2Division of Stem Cells and Tissue Engineering, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2011-03-08 Revised:2011-04-28 Online:2011-08-20 Published:2011-08-20
  • Contact: Hao Peng☆, Doctor, Attending physician, Department of Orthopedic Surgery, Sichuan Provincial Hospital, Chengdu 610072, Sichuan Province, China hhaopeng@163.com
  • About author:Hao Peng☆, Doctor, Attending physician, Department of Orthopedic Surgery, Sichuan Provincial Hospital, Chengdu 610072, Sichuan Province, China hhaopeng@163.com

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Abstract:

BACKGROUND: Amnion can depress the degree of tendon adhesion, but also can induce the immune reaction.
OBJECTIVE: To evaluate the effects of human acellular amniotic membrane (HAAM) on Roman chickens tendon adhesion when the derived tendon materials were used to repair the flexor digitorum profundus tendon defects.
METHODS: The flexor digitorum profundus tendons of three fingers of each claw in 40 Roman chickens were resected and 1 cm defect was made as experimental model. The defects were repaired by three methods respectively (group A: derived tendon materials; group B: derived tendon materials encapsulated by HAAM; group C: autograft).
RESULTS AND CONCLUSION: In group A and C, the tendon grafts were healed exogenously. In group B, the fibroblast infiltration was stopped by HAAM efficiently and the tendon grafts healed endogenously. The degree of adhesion: group B was better than group A and group C, group A was similar with group C. The inflammatory reactions around grafts were group B＞group A＞group C. HAAM lessened the tendon adhesion by mechanically preventing the exogenous healing caused by granulation tissue infiltrating the anastomotic stoma and would be a good biological material in preventing postoperative adhesions of flexor tendon.

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