Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6257-6261.doi: 10.3969/j.issn.1673-8225.2011.33.043

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Intragenic polymorphisms of the aggrecan associated with lumbar disk herination

Tan Ping-xian1, 2, Li Jian3, Sun Xiao-fang4, Yan Deng-lu3, Zhang Zai-heng3, Zhang Hui-min4   

  1. 1Department of Orthopedics, Changping Hospital of Dongguan City, Dongguan 523573, Guangdong Province, China; 2Department of Orthopedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou   510080, Guangdong Province, China ; 3Department of Orthopedics, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou   510150, Guangdong Province, China; 4Department of Gynaecology and Obstetrics, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou   510150, Guangdong Province, China
  • Received:2011-03-06 Revised:2011-06-09 Online:2011-08-13 Published:2011-08-13
  • About author:Tan Ping-xian☆, Studying for doctorate, Associate chief physician, Department of Orthopedics, Changping Hospital of Dongguan City, Dongguan 523573, Guangdong Province, China; Department of Orthopedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China tanpingx@yahoo.cn

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Abstract:

BACKGROUND: Previous studies have shown that aggrecan gene in Han population in southern regions in China shows tandem repetitive sequence polymorphism.
OBJECTIVE: To investigate the association between aggrecan polymorphism and lumbar disk herniation.
METHODS: A total of 102 participants with or without low back pain problem were included in this study. Two groups were used. The study group included 51 lumbar disk herniation participants. The control group included 51 patients without lumbar disk herniation or low back pain or spine diseases. The aggrecan polymorphisms of the two groups were obtained. The Cochran-Mantel-Haenszel test was performed to assess the distributing difference of aggrecan gene polymorphisms between the study group and control group.
RESULTS AND CONCLUSION: Seven alleles were found in the control group, and six alleles were found in the study group. The frequency of allele 27 was the most common form in the study and control groups, and there was no significant difference in the allele polymorphism between these two groups (P > 0.05). The distributing frequency of each allele was basically the same between the control and study groups, i.e., seven and six tandem repetitive sequences of different lengths were found in these two groups, respectively. These findings suggest that no obvious association was found between aggrecan polymorphism and lumbar disc herniation.

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