Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6227-6230.doi: 10.3969/j.issn.1673-8225.2011.33.036

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Repair of articular cartilage defects by tissue engineering

Zhang Yi, Wei Deng-ming, Yin Xiang-xu, Jia Xue-min   

  1. Medical College of Ningbo University, Ningbo  315211, Zhejiang Province, China
  • Received:2011-02-03 Revised:2011-03-02 Online:2011-08-13 Published:2011-08-13
  • Contact: Wei Deng-ming, Doctor, Professor, Medical College of Ningbo University, Ningbo 315211, Zhejiang Province, China weidengming@nbu. edu.cn
  • About author:Zhang Yi★, Studying for master’s degree, Medical College of Ningbo University, Ningbo 315211, Zhejiang Province, China yizaishuiyifang@163.com
  • Supported by:

    Science and Technology Plan Program of Zhejiang Province 2009C33139*

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Abstract:

BACKGROUND: Seed cells, biological stents and growth factors are three major aspects of tissue engineering. How to improve the repair of cartilage defects by tissue engineering has been always the study focus.
OBJIECTIVE: To generally investigate the research progress of cartilage defects by tissue engineering.
METHODS: A computer-based retrieval was performed to search papers published between 2005-2010 in PubMed and CNKI databases using the key words “cartilage, tissue engineering, repair” in English or Chinese language. The papers that address cartilage tissue engineering were included and those with repetitive contents were excluded. 
RESULTS AND CONCLUSION: A total of 167 papers were retrieved and 20 papers were included in the final analysis. Seed cells are the key to cartilage tissue engineering, including chondrocytes, bone marrow mesenchymal stem cells, embryonic stem cells, and gene engineered seed cells. At present, bone marrow mesenchymal stem cells are most used and acquire best application prospect. Biological stents have experienced a long process and develop toward compound and functional application. Various growth factors are essential in tissue engineering. Transforming growth factor, insulin-like growth factor, and bone morphogenetic protein play an important role in repair of cartilage defects.

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