Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6199-6202.doi: 10.3969/j.issn.1673-8225.2011.33.029

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Effect of polygonatum polysaccharide on bone metabolism cytokines in osteoporotic fracture rats

Zeng Gao-feng1, Zhang Zhi-yong1, Lu Li1, Xiao De-qiang1, Zong Shao-hui2, Xiong Chun-xiang3, Zhao Yu-xi3   

  1. 1School of Public Health, 3Post-graduate School, Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China; 2Department of Spinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-02-14 Revised:2011-03-19 Online:2011-08-13 Published:2011-08-13
  • Contact: Zhang Zhi-yong, Professor, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • About author:Zeng Gao-feng☆, Doctor, Associate professor, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China fengfeng_388@126. com
  • Supported by:

    the Scientific Research Foundation of Education Department of Guangxi, No. 302204*; the Science Foundation for Postdoctoral Station of Guangxi Medical University, No. 308084*

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Abstract:

BACKGROUND: Onset of osteoporotic fracture is mainly resulted from reduction of estrogen that forms high-turnover osteoporosis, though this phenomenon can be treated effectively using estrogen, the long-term estrogen replacement therapy can cause many diseases.
OBJECTIVE: To investigate the effect of polygonatum polysaccharide (PSP) on the cytokines of bone metabolism in the osteoporotic fracture rats.
METHODS: Female, 6-month aged SD rats were divided into the control (n=8) and osteoporotic fracture (n=36) groups. After the success model preparation, rats in the osteoporotic fracture group were randomly treated by 0.066 mg/kg estrogen, 400, 200 or 100 mg/kg PSP by intragastric administration, twice per day, for 35 successive days. The expressions of bone gla protein (BGP) and tartrate-resistant acid phosphatase (TRAP) were detected by ELISA.
RESULTS AND CONCLUSION: BGP and TRAP levels were significantly increased in osteoporotic fracture rats. After PSP treatment, the BGP and TRAP levels were significantly decreased in the high dose PSP group. But intervention was not significant in medium and low dose PSP groups. It suggests that PSP can decrease BGP and TRAP expressions in the osteoporotic fracture rats. PSP can promote union of fracture.

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