Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6165-6167.doi: 10.3969/j.issn.1673-8225.2011.33.021

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Effect of a-zearanol on interleukin-1, 6 expressions in a rat model of osteoporotic fracture

Zong Shao-hui1, Wei Bo2, Zeng Gao-feng2, Xiong Chun-xiang3, Zhao Yu-xi3   

  1. 1Department of Spine Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China; 2School of Public Health, 3Postgraduate School, Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-02-15 Revised:2011-04-16 Online:2011-08-13 Published:2011-08-13
  • About author:Zong Shao-hui☆, M.D., Associate professor, Department of Spine Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China xiaohui3008@126. com
  • Supported by:

    the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. Guikeqing0832041*; Scientific Research Foundation of Health Department of Guangxi i Zhuang Autonomous Region, No. GuiweiZ2007046*

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Abstract:

BACKGROUND: a-zearanol (α-ZAL) is a new phytoestrogen that may have some physiological functions of animal estrogen.
OBJECTIVE: To investigate the effects of α-ZAL on interleukin (IL)-1and IL-6 in rats with osteoporotic fracture.
METHODS: Osteoporosis was induced in 40 female 6-week-old Sprague-Dawley rats by bilateral ovariectomy. Thereafter, the right tibia was cut off to establish rat models of fracture. One week later, rats were intragastrically administered 0.066 mg/kg estradiol, or 10, 5, 1 mg/kg α-ZAL and dimethyl sulfoxide; another 10 rats did not underwent ovariectomy, but developed fracture and received intragastric administration of dimethyl sulfoxide. After administration for 35 days, serum level of IL-1 and IL-6 was determined by ELISA.
RESULTS AND CONCLUSION: After ovariectomy, serum level of IL-1 and IL-6 was obviously increased in fracture rats. 5,  1 mg/kg α-ZAL and 0.066 mg/kg estradiol could markedly decrease serum level of IL-1 and IL-6 in osteoporotic fracture rats, but   10 mg/kg α-ZAL did not produce obvious effects. The results showed that α-ZAL could decrease serum level of IL-1 and IL-6 in osteoporotic fracture rats in a dose-dependent manner.

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